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Shorter Injectable-containing MDR/RR-TB Regimen: Pre-treatment evaluation and follow-up
Learning ObjectivesShorter Injectable-containing MDR/RR-TB Regimen: Pre-treatment evaluation and follow-up
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The table below provides the details about the clinical evaluation and laboratory tests that need to be done during Pre-treatment Evaluation (PTE) to initiate patients on shorter injectable-containing Multidrug-resistant (MDR)/ Rifampicin-resistant Tuberculosis (RR-TB) regimens.
| CLINICAL EVALUATION | LABORATORY-BASED EVALUATION |
|---|---|
| History and physical examination | Random Blood Sugar (RBS) |
| Height check | HIV testing following counselling |
| Weight check | Complete blood count (haemoglobin (Hb), Total Leucocyte Count (TLC), Differential Leucocyte Count (DLC), platelet count) |
| Psychiatric evaluation, if required | Liver function tests (including serum proteins) |
| Thyroid-stimulating Hormone (TSH) levels | |
| Urine examination – routine and microscopic | |
| Serum creatinine | |
| Audiometry | |
| Urine pregnancy test (in women of reproductive age) | |
| Chest X-ray | |
| Electrocardiogram (ECG) |
Follow-up Investigations
- Audiometry: Baseline and then every 2 months till Second-line Injectable (SLI) (Kanamycin (Km)/ Amikacin (Am)) course is completed and then, as and when clinically indicated
- Serum creatinine: Baseline and then monthly till SLI course is completed.
The rest of the management would be the same as for shorter all oral Bedaquiline (Bdq) - containing MDR/ RR-TB regimen.
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