Isoniazid [H] Mono/Poly DR-TB Regimen: Pre-treatment Evaluation

Pre-treatment evaluation for any TB patient must include a thorough clinical evaluation by a doctor with:

• History and physical examination
• Height/ weight check
• Random Blood Sugar (RBS) 
• Chest X-ray 
• HIV test

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No additional investigations (except the basic evaluations mentioned above) are required for Isoniazid (H) mono/ poly Drug-resistant TB (DR-TB) patients unless clinically indicated.

The pre-treatment evaluation carried out at the time of treatment initiation can be considered valid for 1 month from the date of the test result and the patient can be reinitiated on a subsequent regimen considering the previously conducted pre-treatment tests.

Active Drug Safety Management and Monitoring (aDSM) treatment initiation form needs to be completed for all DR-TB patients at the time of initiation of each new episode of the treatment.

Resources

• Guidelines for Programmatic Management of Drug-resistant Tuberculosis in India, March 2021.
• WHO Consolidated Guidelines on Tuberculosis: Module 4 - Treatment: Drug-resistant TB Treatment, 2020.

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