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LPA for DR-TB Diagnosis
Learning ObjectivesExplain the role of LPA in the diagnosis of DRTB including both FL and SL LPA.
H5Content
Content
As per the Integrated Drug Resistant Tuberculosis (DR-TB) Diagnostic Algorithm:
- Nucleic Acid Amplification Test (NAAT) are preferred for initial detection of Rifampicin (R) resistance.
- Line Probe Assay (LPA) test is preferred for detection of Isoniazid (H), Fluroquinolones (FQ) and second-line injectable (SLI) drugs resistance.
- When Rifampicin resistance is detected by NAAT (Figure):
- Offer first-line (FL) and second line (SL) LPA
- Direct LPA performed on smear positive specimen or indirect LPA is performed on culture isolate when smear is negative
- When Rifampicin resistance is not detected by NAAT (Figure):
- Offer FL-LPA to detect H resistance
- Direct LPA performed on smear positive specimen or indirect LPA is performed on culture isolate when smear is negative
- If H resistance is detected, SL-LPA is performed to check FQ resistance.
- When Rifampicin resistance is detected by NAAT (Figure):
Figure: Flow Chart to decide FL/SL-LPA after NAAT Results
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Approved in LT-B7
Namrata Thu, 10/03/2022 - 13:55
Approved in LT-B7