Evidence for efficacy of different drugs under TPT

Resources for 6 H:

1. Akolo C, Adetifa I, Shepperd S, Volmink J. Treatment of latent tuberculosis infection in HIV infected persons. Cochrane Database Syst Rev. 2010;(1) Available at: https://pubmed. ncbi.nlm.nih.gov/20091503/. Accessed March 2020.
2. Zenner D, Beer N, Harris RJ, Lipman MC, Stagg HR, van der Werf MJ. Treatment of Latent Tuberculosis Infection. Ann Intern Med. 2017 Aug 1;167(4):248–55.

For 3RH:

Stagg HR, Zenner D, Harris RJ, Muñoz L, Lipman MC, Abubakar I. Treatment of Latent Tuberculosis Infection. Ann Intern Med. 2014 Sep 16;161(6):419–28.
Spyridis NP, Spyridis PG, Gelesme A, Sypsa V, Valianatou M, Metsou F, et al. The effectiveness of a 9-month regimen of isoniazid alone versus 3- and 4-month regimens of isoniazid plus rifampin for treatment of latent tuberculosis infection in children: results of an 11-year randomized study. Clin Infect Dis. 2007 Sep 15;45(6):715–22

For 1HP:

1. Swindells S, Ramchandani R, Gupta A et. al. BRIEF TB/A5279 Study Team. One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis. N Engl J Med. 2019 Mar 14;380(11):1001-1011. doi: 10.1056/NEJMoa1806808. PMID: 30865794; PMCID: PMC6563914.
2 World Health Organization. WHO operational handbook on TB: Module 1 – TB Preventive Treatment, 2020