Management of Prolonged QTcF During Treatment with Shorter/Longer Oral MDR-TB Regimen ​

Management of increased QTcF in Electrocardiogram (ECG) entails looking at the algorithm for the reintroduction of anti-TB drugs (Bedaquiline (Bdq)/ Delamanid (Dlm)/ Fluoroquinolone (FQ)/ Clofazimine (Cfz)) once prolonged QTc has normalized, as shown in the below figure.

Figure: Management of prolonged QTcF during treatment with shorter/ longer oral MDR-TB regimen; Source: Guidelines for PMDT, India 2021, p85.

Resources

• Guidelines for Programmatic Management of Drug-resistant Tuberculosis in India, March 2021.
• WHO Consolidated Guidelines on Tuberculosis: Module 4 - Treatment: Drug-resistant TB Treatment, 2020.

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