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The severity of TB disease is crucial for management strategies and treatment outcomes. 

 

  • The severity of the disease is usually determined by the presence of cavities or bilateral disease on chest radiography or smear positivity in case of pulmonary TB.

 

  • The site of disease is another determinant of the severity of TB. The following are severe forms of TB disease depending on the site:
    • Miliary TB
    • TB disease affecting multiple organs or disseminated TB
    • TB disease of the central nervous system 

 

  • Resistance pattern is another important component determining the severity of TB disease. The severity of the disease increases with an increase in resistance to different TB drugs.

 

  • Comorbidities like HIV and diabetes lead to fast progression to severe forms of TB disease. Thus, early identification of comorbidities and their management is essential to prevent a severe form of TB disease.

 

In children, the occurrence of advanced malnutrition or advanced immunosuppression may also be considered when determining disease severity.

 

 

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Dr. Priyadarshini Wed, 10/01/2024 - 00:49

Shouldn't factors affecting severity of TB cover diet, SES, immunity, etc? Miliary TB and TB disease affecting multiple organs or disseminated TB are the same!