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Shorter Injectable-containing MDR/RR-TB Regimen: Regimen and Duration
Learning ObjectivesThe learning objective is to provide guidance on Shorter Injectable-containing MDR/RR-TB Regimen: Regimen and Duration
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The shorter injectable-containing MDR/RR-TB Regimen consists of 4 to 6 months of intensive phase with high dose moxifloxacin, Kanamycin/Amikacin (injectable), Ethionamide, Clofazimine, Pyrazinamide, high dose isoniazid and ethambutol and a 5-month continuation phase with high dose moxifloxacin, Clofazimine, Pyrazinamide and Ethambutol. This regimen can be written in the following abbreviated form.
(4-6) Mfxh, Km/Am, Eto, Cfz, Z, Hh, E/ (5) Mfxh, Cfz, Z, E
Mfxh- High dose moxifloxacin
Km/Am- Kanamycin/Amikacin
Eto- Ethionamide
Cfz-Clofazimine
Z- Pyrazinamide
Hh -High dose Isoniazid
E- Ethambutol
Note:
- If the intensive phase is prolonged, the injectable agent (Km/Am) is only given three times a week in the extended intensive phase;
- Neither replacement of drug (except the use of Am instead of Km) nor extension of treatment duration (beyond 11 months) is permitted; and
- Pyridoxine is to be given as per weight band.
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Question | Answer 1 | Answer 2 | Answer 3 | Answer 4 | Correct answer | Correct explanation | Page id | Part of Pre-test | Part of Post-test |
Which of these statements is true about the Shorter Injectable-containing MDR/RR-TB regimen and duration? | Any of the drugs can be replaced | Treatment can be extended beyond 11 months if required | Amikacin cannot be used in place of Kanamycin | Pyridoxine has to be given as per weight band | 4 | Pyridoxine is given to counteract the effects of high dose Isoniazid which may cause peripheral neuropathy by Vit B6 deficiency | |||
Mfxh stands for | High dose isoniazid | High dose Moxifloxacin | Moxifloxacin resistance | Isoniazid resistance | 2 | Mfxh stands for High dose Moxifloxacin |
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