{"presentation":{"slides":[{"elements":[{"x":42.48366013071895,"y":43.01075268817204,"width":22.54901960784314,"height":41.0752688172043,"action":{"library":"H5P.Image 1.1","params":{"decorative":false,"contentName":"Image","expandImage":"Expand Image","minimizeImage":"Minimize Image","file":{"path":"images\/file-6729136feb44f.png","mime":"image\/png","copyright":{"license":"U"},"width":632,"height":583}},"subContentId":"6644bd40-6b34-4157-b1d0-54f29bf4bf73","metadata":{"contentType":"Image","license":"U","title":"Untitled Image"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":6.5359477124183005,"y":4.301075268817204,"width":92.5925925925926,"height":15.053763440860214,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"

In 2022, WHO recommended that all patients with MDR\/RR-TB<\/strong>, including those with additional resistance to FQ, stand to benefit from effective all-oral treatment regimens, either shorter or longer, implemented under programmatic conditions. <\/p>\n"},"subContentId":"b03b83d8-3783-4e1e-a4fa-92d0ca29d0c5","metadata":{"contentType":"Text","license":"U","title":"Untitled Text"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":47.930283224400874,"y":17.204301075268816,"width":11.87363834422658,"height":7.526881720430107,"action":{"library":"H5P.Image 1.1","params":{"decorative":false,"contentName":"Image","expandImage":"Expand Image","minimizeImage":"Minimize Image","file":{"path":"images\/file-672913e6c51bd.png","mime":"image\/png","copyright":{"license":"U"},"width":397,"height":127}},"subContentId":"ba723ea6-53b7-40bd-9e44-04e733179696","metadata":{"contentType":"Image","license":"U","title":"Untitled Image"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":5.337690631808279,"y":33.11827956989247,"width":41.61220043572985,"height":34.62365591397849,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"

The 6-month BPaLM regimen<\/strong><\/span>, comprising Bdq, pretomanid (Pa), Lzd (600 mg) and Mfx, may be used programmatically in place of 9-month or longer (\u2265 18 months) regimens in patients (aged \u226514 years) with MDR\/RR-TB who have not had previous exposure to Bdq, Pa and Lzd (defined as more than one month exposure). <\/p>\n"},"subContentId":"cd2e8a85-80af-4a96-a48e-0a7ecd89f51b","metadata":{"contentType":"Text","license":"U","title":"Untitled Text"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":28.32244008714597,"y":88.17204301075269,"width":53.37690631808279,"height":10.75268817204301,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"

This regimen may be used without Mfx (BPaL)<\/strong><\/span> in the case of documented resistance to FQs (in patients with Pre-XDR-TB).<\/p>\n"},"subContentId":"74452447-a8bc-4bbb-843e-d6e6e08af316","metadata":{"contentType":"Text","license":"U","title":"Untitled Text"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":60.67538126361656,"y":32.68817204301075,"width":38.77995642701525,"height":21.72043010752688,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"

Drug susceptibility testing (DST) <\/strong><\/span>to FQ is strongly encouraged, but DST should not delay treatment initiation <\/p>\n"},"subContentId":"630ab5fa-ac0e-41be-b699-99b8a55c7259","metadata":{"contentType":"Text","license":"U","title":"Untitled Text"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":52.287581699346404,"y":62.36559139784946,"width":4.57516339869281,"height":9.032258064516128,"action":{"library":"H5P.Image 1.1","params":{"decorative":false,"contentName":"Image","expandImage":"Expand Image","minimizeImage":"Minimize Image","file":{"path":"images\/file-6729150d1f2e4.png","mime":"image\/png","copyright":{"license":"U"},"width":128,"height":128}},"subContentId":"21b40395-087f-43c2-bebe-c6eeecaa0685","metadata":{"contentType":"Image","license":"U","title":"Untitled Image"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":5.446623093681917,"y":27.311827956989244,"width":91.50326797385621,"height":0.6451612903225806,"action":{"library":"H5P.Shape 1.0","params":{"line":{"borderWidth":"2","borderStyle":"dotted","borderColor":"rgb(196, 196, 196)"},"type":"horizontal-line","shape":{"fillColor":"#ffffff","borderColor":"#000000","borderWidth":"0","borderStyle":"solid","borderRadius":"0"}},"subContentId":"28ea8f0e-2547-4691-9a42-a8526a853414","metadata":{"contentType":"Shapes","license":"U"}},"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false},{"x":35.947712418300654,"y":75.26881720430107,"width":5.446623093681917,"height":10.75268817204301,"action":{"library":"H5P.Image 1.1","params":{"decorative":false,"contentName":"Image","expandImage":"Expand Image","minimizeImage":"Minimize Image","file":{"path":"images\/file-672915ba43ee3.png","mime":"image\/png","copyright":{"license":"U"},"width":128,"height":128}},"subContentId":"f649a6dc-ecfc-4f2c-886d-07171ae35938","metadata":{"contentType":"Image","license":"U","title":"Untitled Image"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":66.44880174291939,"y":73.11827956989247,"width":5.446623093681917,"height":10.75268817204301,"action":{"library":"H5P.Image 1.1","params":{"decorative":false,"contentName":"Image","expandImage":"Expand Image","minimizeImage":"Minimize Image","file":{"path":"images\/file-67291625ee342.png","mime":"image\/png","copyright":{"license":"U"},"width":128,"height":128}},"subContentId":"b877ec14-d9b0-4a58-bac6-68cc663aeae1","metadata":{"contentType":"Image","license":"U","title":"Untitled Image"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":52.287581699346404,"y":30.10752688172043,"width":5.446623093681917,"height":10.75268817204301,"action":{"library":"H5P.Image 1.1","params":{"decorative":false,"contentName":"Image","expandImage":"Expand Image","minimizeImage":"Minimize Image","file":{"path":"images\/file-67291645ece67.png","mime":"image\/png","copyright":{"license":"U"},"width":128,"height":128}},"subContentId":"131d4697-29df-4805-83d0-ce60eb89d4b9","metadata":{"contentType":"Image","license":"U","title":"Untitled Image"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":4.357298474945534,"y":6.451612903225806,"width":92.81045751633987,"height":44.086021505376344,"action":{"library":"H5P.Image 1.1","params":{"decorative":false,"contentName":"Image","expandImage":"Expand Image","minimizeImage":"Minimize Image","file":{"path":"images\/file-67291890f0d8f.png","mime":"image\/png","copyright":{"license":"U"},"width":686,"height":313}},"subContentId":"230b9985-cda7-4b4a-b69c-f174f64372ad","metadata":{"contentType":"Image","license":"U","title":"Untitled Image"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":7.080610021786493,"y":10.32258064516129,"width":83.76906318082789,"height":32.25806451612903,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"

WHO recommended <\/strong>that the nine-month, all-oral, Bdq- containing regimens are preferred<\/span> <\/span><\/strong>over the longer (\u2265 18 months) regimen in adults and children with MDR\/ RR-TB, without previous exposure to second-line treatment (including Bdq), without FQ resistance and with no extensive pulmonary TB disease or severe EP-TB and in patients where BPaLM cannot be given.<\/p>\n\n

In this regimen, two months of Lzd (600 mg) <\/strong><\/span>can be used as an alternative to four months of Eto (6).<\/p>\n"},"subContentId":"ec6b5b3c-9f19-4d05-b7b1-9591d03ecb30","metadata":{"contentType":"Text","license":"U","title":"Untitled Text"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":88.23529411764706,"y":32.25806451612903,"width":8.061002178649238,"height":15.913978494623654,"action":{"library":"H5P.Image 1.1","params":{"decorative":false,"contentName":"Image","expandImage":"Expand Image","minimizeImage":"Minimize Image","file":{"path":"images\/file-6729195a108f8.png","mime":"image\/png","copyright":{"license":"U"},"width":512,"height":512}},"subContentId":"f0d96cd6-7d4a-4404-abf1-b9f256b836b3","metadata":{"contentType":"Image","license":"U","title":"Untitled Image"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":4.357298474945534,"y":55.91397849462365,"width":92.5925925925926,"height":40,"action":{"library":"H5P.Image 1.1","params":{"decorative":false,"contentName":"Image","expandImage":"Expand Image","minimizeImage":"Minimize Image","file":{"path":"images\/file-672919b8528f0.png","mime":"image\/png","copyright":{"license":"U"},"width":686,"height":312}},"subContentId":"6b7d4bae-66f3-489d-9f90-257dd4d84e93","metadata":{"contentType":"Image","license":"U","title":"Untitled Image"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":6.5359477124183005,"y":64.51612903225806,"width":81.69934640522877,"height":23.65591397849462,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"

Patients with extensive forms of DR-TB (e.g., XDR-TB) or those who are not eligible for or have failed shorter treatment regimens will benefit from <\/strong><\/span>individualized longer (\u226518 months) regimens <\/strong><\/span>designed using the priority grouping of medicines recommended in current WHO guidelines.<\/p>\n"},"metadata":{"contentType":"Text","license":"U","title":"Untitled Text"},"subContentId":"d44ba9c2-869e-4a74-a437-cbf8d748c26e"},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":87.14596949891067,"y":77.41935483870967,"width":8.056486860033237,"height":15.913978494623654,"action":{"library":"H5P.Image 1.1","params":{"decorative":false,"contentName":"Image","expandImage":"Expand Image","minimizeImage":"Minimize Image","file":{"path":"images\/file-67291a1152036.png","mime":"image\/png","copyright":{"license":"U"},"width":128,"height":128}},"metadata":{"contentType":"Image","license":"U","title":"Untitled Image"},"subContentId":"0fe70530-8a72-423c-a362-92120f51495d"},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}}],"keywordListEnabled":true,"globalBackgroundSelector":{},"keywordListAlwaysShow":false,"keywordListAutoHide":false,"keywordListOpacity":90},"override":{"activeSurface":false,"hideSummarySlide":false,"summarySlideSolutionButton":true,"summarySlideRetryButton":true,"enablePrintButton":false,"social":{"showFacebookShare":false,"facebookShare":{"url":"@currentpageurl","quote":"I scored @score out of @maxScore on a task at @currentpageurl."},"showTwitterShare":false,"twitterShare":{"statement":"I scored @score out of @maxScore on a task at @currentpageurl.","url":"@currentpageurl","hashtags":"h5p, course"},"showGoogleShare":false,"googleShareUrl":"@currentpageurl"}},"l10n":{"slide":"Slide","score":"Score","yourScore":"Your Score","maxScore":"Max Score","total":"Total","totalScore":"Total Score","showSolutions":"Show solutions","retry":"Retry","exportAnswers":"Export text","hideKeywords":"Hide sidebar navigation menu","showKeywords":"Show sidebar navigation menu","fullscreen":"Fullscreen","exitFullscreen":"Exit fullscreen","prevSlide":"Previous slide","nextSlide":"Next slide","currentSlide":"Current slide","lastSlide":"Last slide","solutionModeTitle":"Exit solution mode","solutionModeText":"Solution Mode","summaryMultipleTaskText":"Multiple tasks","scoreMessage":"You achieved:","shareFacebook":"Share on Facebook","shareTwitter":"Share on Twitter","shareGoogle":"Share on Google+","summary":"Summary","solutionsButtonTitle":"Show comments","printTitle":"Print","printIngress":"How would you like to print this presentation?","printAllSlides":"Print all slides","printCurrentSlide":"Print current slide","noTitle":"No title","accessibilitySlideNavigationExplanation":"Use left and right arrow to change slide in that direction whenever canvas is selected.","accessibilityCanvasLabel":"Presentation canvas. Use left and right arrow to move between slides.","accessibilityProgressBarLabel":"Choose slide to display","containsNotCompleted":"@slideName contains not completed interaction","containsCompleted":"@slideName contains completed interaction","slideCount":"Slide @index of @total","containsOnlyCorrect":"@slideName only has correct answers","containsIncorrectAnswers":"@slideName has incorrect answers","shareResult":"Share Result","accessibilityTotalScore":"You got @score of @maxScore points in total","accessibilityEnteredFullscreen":"Entered fullscreen","accessibilityExitedFullscreen":"Exited fullscreen","confirmDialogHeader":"Submit your answers","confirmDialogText":"This will submit your results, do you want to continue?","confirmDialogConfirmText":"Submit and see results","slideshowNavigationLabel":"Slideshow navigation"}}

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WHO recommendation for newer, shorter, oral regimens

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WHO recommendation for newer, shorter, oral regimens

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