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Relative contraindications<\/strong><\/td>\n\t\t\t

Notes <\/strong><\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

Concurrent use of medications that have known<\/div>\n\n\t\t\t

interactions or overlapping toxicities<\/div>\n\n\t\t\t

with BPaLM<\/div>\n\t\t\t<\/td>\n\t\t\t

1. Use of strong inhibitors or inducers of cytochrome P450 enzyme*
\n\t\t\t2. Drugs that prolong the QT interval (anti-fungals, antiarrhythmics, antipsychotics etc.)
\n\t\t\t3. Drugs that increase serotonin levels and other serotoninergic
\n\t\t\t4. Monoamine Oxidase Inhibitors (MAOIs) or prior use within 2 weeks of treatment
\n\t\t\t5. Currently on serotoninergic antidepressants\/tricyclic antidepressants or prior use within 3 days of treatment
\n\t\t\t6. Concomitant use of any drug know to induce myelosuppression
\n\t\t\t <\/td>\n\t\t<\/tr>\n\t\t

High risk of cardiac arrhythmia<\/td>\n\t\t\t

1. Baseline & repeat ECGs after 6 hours show QTcF> 500 ms with normal electrolytes
\n\t\t\t2. History of additional risk for Torsade de Pointers-syncopal episodes, ventricular arrhythmias, heart failure or severe coronary artery disease, family history of long- QT syndrome
\n\t\t\t3. Clinically significant cardiac arrythmias<\/td>\n\t\t<\/tr>\n\t<\/tbody>\n<\/table>\n\n

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Relative contraindications<\/strong><\/td>\n\t\t\t	Notes <\/strong><\/td>\n\t\t<\/tr>\n\t\t
\n\t\t\t Severe anaemia, thrombocytopenia<\/div>\n\n\t\t\t or leukopenia<\/div>\n\t\t\t<\/td>\n\t\t\t	1. Hb level < 8.0 g\/dL \n\t\t\t2. Platelet count < 75 000\/mm3 \n\t\t\t3. Absolute neutrophil count < 1000\/mm3<\/td>\n\t\t<\/tr>\n\t\t
Significant hepatic dysfunction<\/td>\n\t\t\t	1. AST\/ALT >3.0 x ULN, irrespetive of symptoms of liver disease \n\t\t\t2. Total bilirubin > 2.0 x ULN<\/td>\n\t\t<\/tr>\n\t\t
Severe renal failure <\/td>\n\t\t\t	1. Serum creatinine > 3.0 x ULN \n\t\t\t2. Owing to limited experience with the use of this regimen, caution should be excercised in patients with severe renal failure<\/td>\n\t\t<\/tr>\n\t\t
Severe neuropathy<\/td>\n\t\t\t	1. Peripeheral neuropathy of grade 3 or grade 4<\/td>\n\t\t<\/tr>\n\t<\/tbody>\n<\/table>\n\n <\/div>\n"},"metadata":{"contentType":"Table","license":"U","title":"Untitled Table"},"subContentId":"c4a70fcb-0826-46b0-8cc8-8d1c72db202f"},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}}],"keywordListEnabled":true,"globalBackgroundSelector":{},"keywordListAlwaysShow":false,"keywordListAutoHide":false,"keywordListOpacity":90},"override":{"activeSurface":false,"hideSummarySlide":false,"summarySlideSolutionButton":true,"summarySlideRetryButton":true,"enablePrintButton":false,"social":{"showFacebookShare":false,"facebookShare":{"url":"@currentpageurl","quote":"I scored @score out of @maxScore on a task at @currentpageurl."},"showTwitterShare":false,"twitterShare":{"statement":"I scored @score out of @maxScore on a task at @currentpageurl.","url":"@currentpageurl","hashtags":"h5p, course"},"showGoogleShare":false,"googleShareUrl":"@currentpageurl"}},"l10n":{"slide":"Slide","score":"Score","yourScore":"Your Score","maxScore":"Max Score","total":"Total","totalScore":"Total Score","showSolutions":"Show solutions","retry":"Retry","exportAnswers":"Export text","hideKeywords":"Hide sidebar navigation menu","showKeywords":"Show sidebar navigation menu","fullscreen":"Fullscreen","exitFullscreen":"Exit fullscreen","prevSlide":"Previous slide","nextSlide":"Next slide","currentSlide":"Current slide","lastSlide":"Last slide","solutionModeTitle":"Exit solution mode","solutionModeText":"Solution Mode","summaryMultipleTaskText":"Multiple tasks","scoreMessage":"You achieved:","shareFacebook":"Share on Facebook","shareTwitter":"Share on Twitter","shareGoogle":"Share on Google+","summary":"Summary","solutionsButtonTitle":"Show comments","printTitle":"Print","printIngress":"How would you like to print this presentation?","printAllSlides":"Print all slides","printCurrentSlide":"Print current slide","noTitle":"No title","accessibilitySlideNavigationExplanation":"Use left and right arrow to change slide in that direction whenever canvas is selected.","accessibilityCanvasLabel":"Presentation canvas. Use left and right arrow to move between slides.","accessibilityProgressBarLabel":"Choose slide to display","containsNotCompleted":"@slideName contains not completed interaction","containsCompleted":"@slideName contains completed interaction","slideCount":"Slide @index of @total","containsOnlyCorrect":"@slideName only has correct answers","containsIncorrectAnswers":"@slideName has incorrect answers","shareResult":"Share Result","accessibilityTotalScore":"You got @score of @maxScore points in total","accessibilityEnteredFullscreen":"Entered fullscreen","accessibilityExitedFullscreen":"Exited fullscreen","confirmDialogHeader":"Submit your answers","confirmDialogText":"This will submit your results, do you want to continue?","confirmDialogConfirmText":"Submit and see results","slideshowNavigationLabel":"Slideshow navigation"}}

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Relative contraindications Criteria for BPaLM

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