{"presentation":{"slides":[{"elements":[{"x":3.2679738562091503,"y":47.31182795698924,"width":92.5925925925926,"height":51.61290322580645,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"

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The dose reduction of the Lzd to 300, because of grade 3-4 intolerance, can be considered after 09 weeks. If dose of Lzd is reduced to 300 mg the period of the BPaLM regimen will be extended upto 39 weeks<\/span><\/p>\n\t<\/li>\n\t
\n\t
In case of grade 3-4 intolerance to FQ, drop Mfx, complete the rest of the regimen as BPaL and extend the treatment up to 39 weeks.<\/span><\/p>\n\t<\/li>\n\t
\n\t
Extension of treatment upto 39 weeks should be done with strict clinical evaluation and smear\/ culture microbiological follow-up at monthly interval. It should be done with due precautions for patients with a high number of missed Lzd dosages and switching to an individualized longer oral M\/XDR-TB regimen may be considered instead of a BPaL extension. <\/span><\/p>\n\t<\/li>\n<\/ol>\n\n
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In the event of intolerance (grade 3 or 4) to Bdq, Pa or Linezolid, when re-challenge is not possible within 4 weeks of de-challenge to address the intolerance or when resistance is detected, discontinue BPaLM regimen permanently <\/span><\/strong>and declare the outcome as \u2018treatment failed'.<\/span><\/strong><\/p>\n\n
Once a patient is declared as \u2018treatment failed\u2019 and assessed for an individualized longer oral M\/XDR-TB regimen, appropriate modifications using replacement drug sequence <\/strong><\/span>as per the Guidelines for PMDT in India \u2013 2021 will be applicable in most of the patients. <\/p>\n"},"subContentId":"35a6da15-5f08-4549-8c88-9244ea5d563a","metadata":{"contentType":"Text","license":"U","title":"Untitled Text"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":5.010893246187364,"y":6.236559139784946,"width":7.734204793028323,"height":15.268817204301074,"action":{"library":"H5P.Image 1.1","params":{"decorative":false,"contentName":"Image","expandImage":"Expand Image","minimizeImage":"Minimize Image","file":{"path":"images\/file-672a28318a13c.png","mime":"image\/png","copyright":{"license":"U"},"width":128,"height":128}},"subContentId":"8bfdd4af-9fa5-40be-9d62-a9a217e669a8","metadata":{"contentType":"Image","license":"U","title":"Untitled Image"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":5.446623093681917,"y":23.65591397849462,"width":7.729872527869728,"height":15.268817204301074,"action":{"library":"H5P.Image 1.1","params":{"decorative":false,"contentName":"Image","expandImage":"Expand Image","minimizeImage":"Minimize Image","file":{"path":"images\/file-672a284b8d4cd.png","mime":"image\/png","copyright":{"license":"U"},"width":128,"height":128}},"metadata":{"contentType":"Image","license":"U","title":"Untitled Image"},"subContentId":"2a83c8c0-acb8-4b76-be15-6cf82ccd1384"},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}}],"keywordListEnabled":true,"globalBackgroundSelector":{},"keywordListAlwaysShow":false,"keywordListAutoHide":false,"keywordListOpacity":90},"override":{"activeSurface":false,"hideSummarySlide":false,"summarySlideSolutionButton":true,"summarySlideRetryButton":true,"enablePrintButton":false,"social":{"showFacebookShare":false,"facebookShare":{"url":"@currentpageurl","quote":"I scored @score out of @maxScore on a task at @currentpageurl."},"showTwitterShare":false,"twitterShare":{"statement":"I scored @score out of @maxScore on a task at @currentpageurl.","url":"@currentpageurl","hashtags":"h5p, course"},"showGoogleShare":false,"googleShareUrl":"@currentpageurl"}},"l10n":{"slide":"Slide","score":"Score","yourScore":"Your Score","maxScore":"Max Score","total":"Total","totalScore":"Total Score","showSolutions":"Show solutions","retry":"Retry","exportAnswers":"Export text","hideKeywords":"Hide sidebar navigation menu","showKeywords":"Show sidebar navigation menu","fullscreen":"Fullscreen","exitFullscreen":"Exit fullscreen","prevSlide":"Previous slide","nextSlide":"Next slide","currentSlide":"Current slide","lastSlide":"Last slide","solutionModeTitle":"Exit solution mode","solutionModeText":"Solution Mode","summaryMultipleTaskText":"Multiple tasks","scoreMessage":"You achieved:","shareFacebook":"Share on Facebook","shareTwitter":"Share on Twitter","shareGoogle":"Share on Google+","summary":"Summary","solutionsButtonTitle":"Show comments","printTitle":"Print","printIngress":"How would you like to print this presentation?","printAllSlides":"Print all slides","printCurrentSlide":"Print current slide","noTitle":"No title","accessibilitySlideNavigationExplanation":"Use left and right arrow to change slide in that direction whenever canvas is selected.","accessibilityCanvasLabel":"Presentation canvas. Use left and right arrow to move between slides.","accessibilityProgressBarLabel":"Choose slide to display","containsNotCompleted":"@slideName contains not completed interaction","containsCompleted":"@slideName contains completed interaction","slideCount":"Slide @index of @total","containsOnlyCorrect":"@slideName only has correct answers","containsIncorrectAnswers":"@slideName has incorrect answers","shareResult":"Share Result","accessibilityTotalScore":"You got @score of @maxScore points in total","accessibilityEnteredFullscreen":"Entered fullscreen","accessibilityExitedFullscreen":"Exited fullscreen","confirmDialogHeader":"Submit your answers","confirmDialogText":"This will submit your results, do you want to continue?","confirmDialogConfirmText":"Submit and see results","slideshowNavigationLabel":"Slideshow navigation"}}

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Extension criterion for BPaLM regimen

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