Treatment Extension in Isoniazid [H] Mono/Poly DR-TB Regimen

The standard duration of the H Mono/ Poly DR-TB regimen is 6 months.

The treatment duration may be extended in the following conditions:

• Patients with extensive disease
• Uncontrolled comorbidity
• Extra-pulmonary TB
• Smear at the end of month 4 is found positive
• When the regimen is modified

Whenever extending treatment, always it is extended directly to 9 months. There is no monthly extension in this regimen.

In patients who remain sputum smear-positive at the end of month 5 or later, the treatment outcome will be declared as ‘treatment failed’ and the patient will be re-evaluated as per the diagnostic algorithm as a non-responder.

Resources

• Guidelines for Programmatic Management of Drug-resistant Tuberculosis in India, March 2021.
• WHO Consolidated Guidelines on Tuberculosis: Module 4- Treatment: Drug-resistant TB Treatment, 2020.

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