- Learning Objectives
To discuss how TB progresses to TB disease following TB exposure in some individuals.
To bring out the difference between TB exposure, TB Infection and the TB disease following TB exposure.
After exposure to infective droplets containing M.tb, only a small proportion gets infected and further progresses to active TB disease.
- Majority of those that get infected persist in a stage of clinical latency known as TB infection (previously known as Latent TB infection). They do not have TB disease and do not show any symptoms of TB and no evidence of any TB related changes on chest X-ray.
- A small proportion of those with prior infection may progress to active TB disease due to various environmental/ agent/ host factors.
Figure: Flow chart for TB disease progression
- Understanding delayed T-Cell Priming, Lung Recruitment, and AirwayLuminal T-Cell Responses in Host defence against Pulmonary Tuberculosis
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