Content Status

Type

Linked Node

H5Content
Content

The dosage for Drug-resistant TB (DR-TB) drugs used in the regimen by weight bands for adults are enumerated in the table below.

 

Table: Weight Band-wise Drug Dosage of DR-TB Drugs for Adults; Source: Guidelines for PMDT, India 2021, pp.51,64.
SR NO DRUGS 16-29 KG 30-45 KG 46-70 KG >70 KG
1 Levofloxacin (Lfx) 250 mg 750 mg 1000 mg 1000 mg
2 Moxifloxacin (Mfx) 200 mg 400 mg 400 mg 400 mg
3 High dose Mfx (Mfxh) 400 mg 600 mg 600 mg 600 mg
4 Bedaquiline (Bdq)

Week 0–2: Bdq 400 mg daily

Week 3–24: Bdq 200 mg 3 times per week

     
5 Clofazimine (Cfz) 50 mg 100 mg 100 mg 200 mg
6 Cycloserine (Cs)3 250 mg 500 mg 750 mg 1000 mg
7 Linezolid (Lzd) 300 mg 600 mg 600 mg 600 mg
8 Delamanid (Dlm)

50 mg twice daily (100 mg) for 24 weeks in 6-11 years of age

 100 mg twice daily (200 mg) for 24 weeks for ≥12 years of age

     
9 Amikacin (Am)1 500 m 750 mg 750 mg 1000 mg
10 Pyrazinamide (Z) 750 mg 1250 mg 1750 mg 2000 mg
11 Ethionamide (Eto)3 375 mg 500 mg 750 mg 1000 mg
12 Na - PAS (60% weight/ vol)2,3  10 gm 14 gm 16 gm 22 gm
13 Ethambutol (E) 400 mg 800 mg 1200 mg 1600 mg
14 Imipenem - Cilastatin (Imp-Cln)3 2 vials (1 g + 1 g) bd (to be used with Clavulanic acid)      
15 Meropenems (Mpm)3 1000 mg three times daily (alternative dosing is 2000 mg twice daily      
16 Amoxicillin-Clavulanate (Amx-Clv) (to be given with Carbapenems only) 875/125 mg bd 875/125 mg bd 875/125 mg bd 875/125 mg bd
17 High-dose H (Hh) 300 mg 600 mg 900 mg 900 mg
18 Rifampicin (R) 300 mg 450 mg 600 mg 750 mg
19 Pyridoxine (Pdx) 50 mg 100 mg 100 mg 100 mg

1For adults more than 60 yrs of age, dose of Second Line Injectable (SLI) should be reduced to 10 mg/kg (max up to 750 mg)

2In patients on Para-aminosalicylic Acid (PAS) with 80% weight/volume the dose will be changed to 7.5 gm (16-29 kg); 10 gm (30- 45 kg); 12 gm (46-70 kg) and 16 gm (>70 kg)

3Drugs can be given in divided doses in a day in the event of intolerance

 

Resources

 

 

Kindly provide your valuable feedback on the page to the link provided HERE

 

Content Creator

Reviewer