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  • Treatment Adherence for individuals taking TPT

    Learning Objectives

    The learner will be able to 

    • Discuss the significance of Treatment Adherence for individuals taking TPT
    • State the criteria for completion of TPT among contacts of persons with DR-TB
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Content

Adherence to the Tuberculosis Preventive Treatment (TPT) course and treatment completion are important determinants of clinical benefit, both at individual and population levels.

  • Develop a personal adherence plan with the support of the family member, caregiver or health worker as per the treatment regimen being provided.
  • Treatment support and adherence monitoring will be like that of the index patient. 
  • Give first preference to the family member to be the treatment provider in consultation with the person. 
  • Use of digital platforms (tele/ video calls, 99DOTS/ MERM), counting empty blisters, refill monitoring etc., to strengthen adherence monitoring. 
  • Irregular or inadequate treatment reduces the protective efficacy of TPT regimen.
  • Poor adherence or early cessation of TPT can potentially increase the risk of the individual developing TB including Drug-resistant Tuberculosis (DR-TB) (although not supported by existing evidence from research settings).
  • It is known that the efficacy of TPT is greatest if at least 80% of the doses are taken within the duration of the regimen. The total number of doses taken is also a key determinant of the extent of TB prevention. 

The criteria for completion of TPT among DR-TB contacts have been given in the table below.

 

Table: Criteria for completion of TPT among DR-TB contacts; Source: Guidelines for PMDT in India, 2021.
DOSES TOTAL DURATION IN MONTHS EXPECTED NO. OF DOSES 80% OF RECOMMENDED DOSES (DAYS) EXTENDED TIME FOR TREATMENT COMPLETION (DAYS) (TREATMENT DURATION + 33% ADDITIONAL TIME)
6Lfx (daily) 6 180 144 239
4R (daily) 4 120 96 160

 

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Comments

Dr. Priyadarshini Sat, 24/02/2024 - 07:10

Criteria for completion of TPT among contacts of persons with DR-TB can be a separate content page