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The potential adverse drug events that can occur when using drugs in the H mono/ poly DR-TB regimen are tabulated below:

 

Table: Possible Adverse Events due to Drugs in H Mono/ Poly DR-TB Regimen; Source: Guidelines for PMDT, India, 2021, p83.
ADVERSE DRUG EVENTS SUSPECTED DRUG(S)
Hepatitis Rifampicin (R), Pyrazinamide (Z)
QT prolongation Fluoroquinolone (FQ), Clofazimine (Cfz)
Rash, allergic reaction and anaphylaxis Any drug
Gastrointestinal symptoms Z, Ethambutol (E), Cfz, FQs
Giddiness FQ, Z
Arthralgia Z, FQ
Peripheral neuropathy FQ, E
Depression FQ
Psychotic symptoms FQ
Seizures FQ
Tendonitis and tendon rupture FQ
Vestibular toxicity (tinnitus and dizziness) FQ
Optic neuritis E, Linezolid (Lzd), Cfz
Metallic taste FQ
Superficial fungal infection and thrush FQ

 

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