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Adverse Drug Events: H Mono/Poly DR-TB Regimen
Learning ObjectivesAdverse Drug Events: H Mono/Poly DR-TB Regimen
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The potential adverse drug events that can occur when using drugs in the H mono/ poly DR-TB regimen are tabulated below:
ADVERSE DRUG EVENTS | SUSPECTED DRUG(S) |
---|---|
Hepatitis | Rifampicin (R), Pyrazinamide (Z) |
QT prolongation | Fluoroquinolone (FQ), Clofazimine (Cfz) |
Rash, allergic reaction and anaphylaxis | Any drug |
Gastrointestinal symptoms | Z, Ethambutol (E), Cfz, FQs |
Giddiness | FQ, Z |
Arthralgia | Z, FQ |
Peripheral neuropathy | FQ, E |
Depression | FQ |
Psychotic symptoms | FQ |
Seizures | FQ |
Tendonitis and tendon rupture | FQ |
Vestibular toxicity (tinnitus and dizziness) | FQ |
Optic neuritis | E, Linezolid (Lzd), Cfz |
Metallic taste | FQ |
Superficial fungal infection and thrush | FQ |
Resources
- Guidelines for Programmatic Management of Drug Resistant Tuberculosis in India, March 2021.
- WHO Consolidated Guidelines on Tuberculosis: Module 4 - Treatment: Drug resistant TB Treatment, 2020.
- Technical and Operational Guidelines for TB in India, 2016.
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