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Longer Oral M/XDR-TB: Regimen and Duration
Learning ObjectivesDescribe and learn about Longer Oral M/XDR-TB: Regimen and Duration
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Longer oral Multi (M)/ Extensive Drug-resistant (XDR) -TB treatment is specified with a definite regime and duration.
Regimen: (18-20) Levofloxacin (Lfx), Bedaquiline (Bdq) (6 months or longer), Linezolid# (Lzd), Clofazimine (Cfz), Cycloserine (Cs) (# dose of Lzd will be tapered to 300 mg after the initial 6–8 months of treatment)
- Duration: 18-20 months
- No separate Intensive Phase (IP) and Continuation Phase (CP).
- Bdq will be given for 6 months and extended beyond 6 months as an exception.
- Pyridoxine should be given to all Drug-resistant TB (DR-TB) patients as per the weight bands.
- For Extensively Drug-resistant TB (XDR-TB) patients, the duration of a longer oral XDR-TB regimen would be for 20 months.
Resources
- Guidelines for Programmatic Management of Drug-Resistant Tuberculosis in India, March 2021.
- WHO Consolidated Guidelines on Tuberculosis: Module 4 – Treatment: Drug-resistant TB Treatment, 2020.
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