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Shorter Oral Bedaquiline-containing MDR/RR-TB Regimen: Dosage of Drugs for Adults
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In adults, the dosage of drugs for a shorter oral Bedaquiline (Bdq) - containing Multi-drug Resistant (MDR)/ Rifampicin-resistant Tuberculosis (RR-TB) regimen, varies according to their weight.
The table below provides drug dosages for adult patients, according to their weight bands, in a shorter oral Bedaquiline-containing MDR/RR-TB regimen.
| Sr No | Drugs | 16-29 kg | 30-45 kg | 46-70 kg | >70 kg |
|---|---|---|---|---|---|
| 1 | High dose H (Hh) | 300 mg | 600 mg | 900 mg | 900 mg |
| 2 | Ethambutol (E) | 400 mg | 800 mg | 1200 mg | 1600 mg |
| 3 | Pyrazinamide (Z) | 750 mg | 1250 mg | 1750 mg | 2000 mg |
| 4 | Levofloxacin (Lfx) | 250 mg | 750 mg | 1000 mg | 1000 mg |
| 5 | Bedaquiline (Bdq) |
Week 0–2: Bdq 400 mg daily Week 3–24: Bdq 200 mg 3 times per week |
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| 6 | Clofazimine (Cfz) | 50 mg | 100 mg | 100 mg | 200 mg |
| 7 | Ethionamide (Eto)* | 375 mg | 500 mg | 750 mg | 1000 mg |
| 8 | Pyridoxine (Pdx) | 50 mg | 100 mg | 100 mg | 100 mg |
| *Drugs can be given in divided doses in a day in the event of intolerance. | |||||
Resources
- Guidelines for Programmatic Management of Drug-resistant Tuberculosis in India, March 2021.
- The Use of Bedaquiline in the Treatment of Multidrug-resistant Tuberculosis: Interim Policy Guidance, 2013.
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