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Drugs that are part of the shorter Bedaquiline (Bdq)-containing regimen have some typical side effects which need close monitoring of Drug Resistant-TB (DR-TB) patients while providing the treatment.
| Adverse Drug Events | Causative Drugs |
|---|---|
| QT prolongation | Bdq, Fluoroquinolone (FQ), Clofazimine (Cfz) |
| Rash, allergic reaction and anaphylaxis | Any drug |
| Gastrointestinal symptoms | Ethionamide (Eto), Pyrazinamid (Z), Ethambutol (E), Bdq, Cfz, FQs, Isoniazid(H) |
| Diarrhoea and/or flatulence | Eto |
| Hepatitis | Z, H, Eto, Bdq |
| Giddiness | Eto, FQ, Z |
| Hypothyroidism | Eto |
| Arthralgia | Z, FQ, Bdq |
| Peripheral neuropathy | H, FQ, rarely Eto, E |
| Headache | Bdq |
| Depression | FQ, H, Eto |
| Psychotic symptoms | Isoniazid (H), FQ |
| Suicidal ideation | H, Eto |
| Seizures | H, FQ |
| Tendonitis and tendon rupture | FQ |
| Vestibular toxicity (tinnitus and dizziness) | FQs, H, Eto |
| Optic neuritis | E, Lzd, Eto, Cfz, H |
| Metallic taste | Eto, FQs |
| Gynaecomastia | Eto |
| Alopecia | H, Eto |
| Superficial fungal Infection and thrush | FQ |
| Dysglycaemia and Hyperglycaemia | Eto |
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