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Discuss the parts of the CBNAAT/ GeneXpert Cartridge and its functions.

Since the test offers quick high sensitivity/specificity diagnosis TB and simultaneous diagnosis of RIF resistance, it is indicated for use in NTEP in the following cases.

Indications for use:

1. Detection of TB in high risk Presumptive TB with high vulnerability/ Risk (such as previous history of TB, with X-ray abnormalities, HIV, Diabetes) or for use in Key populations for fast tracking diagnosis.
2. Detection of TB & DRTB in cases with high risk of DRTB (such as contacts of DR-TB)
3. Detection of RIF resistance in all TB notified cases.

Describe the various steps in the CBNAAT Testing process.

1. Sample Processing
2. Loading Sample into cartridge
3. Setting up the machine to run the test
4. Loading the cartridge
5. Obtaining the results  

The test simultaneously detects Mycobacterium tuberculosis complex (MTBC) and resistance to rifampicin (RIF)

Test Performance Parameters: Sensitivity Specificity for MTB; Sensitivity Specificity for RIF; TAT is less than 2 hours.I

Test was endorsed by WHO for use in National TB Programs in 2010 and introduced for scaled up in India in 2015-16.

This test is expected to eventually be used as the first choice test for diagnosis of TB.

Discuss the various norms and requirement to establish the same.

Provide an overview of the standards of TB care in India and its purpose. 

Discuss the factors that increase the probability of Mtb. to become drug resistant.

Discuss the global burden of TB-HIV under various parameters and the importance of the dual pandemic. Mention the major countries where both epidemics are considered to be important.

Give an outline of DR-TB situation in India. Give Incidence and prevalence, why India should bother, and where does India stand in Global scenario as far as DR-TB is concerned?

Discuss the global burden of DR-TB under various parameters and historical trend.